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Tg(Slc6a4-cre/ERT2)EZ8Gsat
Transgene Detail
Summary
Symbol: Tg(Slc6a4-cre/ERT2)EZ8Gsat
Name: transgene insertion EZ8, GENSAT Project at Rockefeller University
MGI ID: MGI:4367236
Synonyms: Founder Line EZ8, Tg(Slc6a4-cre/Esr1)8Gsat
Transgene: Tg(Slc6a4-cre/ERT2)EZ8Gsat  Location: unknown  
Alliance: Tg(Slc6a4-cre/ERT2)EZ8Gsat page
Transgene
origin
Strain of Origin:  FVB/N
Project Collection: GENSAT
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tg(Slc6a4-cre/ERT2)EZ8Gsat expression driven by 1 gene
 
Mutation details: This transgene contains the coding sequence for the Cre-ERT2 fusion protein, followed by a polyadenylation signal, inserted into a mouse genomic artificial chromosome (BAC) at the ATG transcription initiation codon of the solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 gene so that expression of the tamoxifen-activated recombinase is driven by the regulatory sequences of the mouse gene. ERT2 is a triply mutated (G400V, M543A, L544A) human estrogen receptor ligand-binding domain that renders the fusion protein highly sensitive to activation by 4-hydroxytamoxifen, but unresponsive to the receptor's native ligands. (J:100256, J:145110)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Slc6a4 (mouse)
Summary of all recombinase alleles driven by Slc6a4.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:100256 The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY), MGI download of GENSAT transgene data. Database Download. 2005;
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory