Ptprctm1(cre)Medv
Targeted Allele Detail
|
|
| Symbol: |
Ptprctm1(cre)Medv |
| Name: |
protein tyrosine phosphatase receptor type C; targeted mutation 1, Alexander Medvinsky |
| MGI ID: |
MGI:4367466 |
| Synonyms: |
CD45-Cre |
| Gene: |
Ptprc Location: Chr1:137990599-138103446 bp, - strand Genetic Position: Chr1, 60.73 cM
|
| Alliance: |
Ptprctm1(cre)Medv page
|
|
| Germline Transmission: |
Earliest citation of germline transmission:
J:152523
|
| Parent Cell Line: |
E14 (ES Cell)
|
| Strain of Origin: |
129P2/OlaHsd
|
|
| Allele Type: |
|
Targeted (Recombinase) |
| Mutation: |
|
Insertion
|
| |
|
Ptprctm1(cre)Medv expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Ptprc (MGI:97810) |
|
|
| |
|
Mutation details: The Cre recombinase encoding cDNA sequence, followed by the SV40 polyadenylation signal and a FRT-flanked puromycin resistance cassette, was inserted at the ATG translation initiation site in the second exon of the protein tyrosine phosphatase, receptor type, C (CD45) gene. The selection cassette was deleted by transient expression of FLPe in the correctly targeted ES cells. In mice bearing this allele and a GFP reporter transgene, fluorescence was observed only in CD45+ cells in the bone marrow, thymus, spleen and peripheral blood; the proportion of fluorescing cells of a given type appeared to correlate with the strength of CD45 expression.
(J:152523)
|
|
|
|
Activity: |
 Tissue activity of this recombinase allele
|
|
Driver:
|
Ptprc
(mouse)
|
| |
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
| Carrying any Ptprc Mutation: |
189 strains or lines available
|
|
| Original: |
J:152523 Yang J, et al., Transgenic tools for analysis of the haematopoietic system: knock-in CD45 reporter and deletor mice. J Immunol Methods. 2008 Sep 15;337(2):81-7 |
| All: |
5 reference(s) |
|
Analysis Tools
