Tg(Nes-cre/ERT2)1Imayo Transgene Detail MGI Mouse (MGI:4398673)

Tg(Nes-cre/ERT2)1Imayo
Transgene Detail

Summary

Symbol:	Tg(Nes-cre/ERT2)1Imayo
Name:	transgene insertion 1, Itaru Imayoshi
MGI ID:	MGI:4398673
Synonyms:	Nestin-CreER.line1, Tg(Nes-cre/ERT2)1Kag
Transgene:	Tg(Nes-cre/ERT2)1Imayo Location: unknown
Alliance:	Tg(Nes-cre/ERT2)1Imayo page

Transgene
origin

Strain of Origin:

C57BL/6

Transgene
description

Transgene Type:

Transgenic (Inducible, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Tg(Nes-cre/ERT2)1Imayo expression driven by 1 gene

Mutation details: This transgene consists of a 5.8 kb fragment of the rat Nes promoter and a 1.8 kb fragment of the second intron of Nes driving expression of a tamoxifen-inducible form of cre recombinase followed by an SV40 poly A sequence. Three lines were created (lines 1, 4, and 5-1) with differing levels of activity (high, medium, and low, respectively) and leakiness (high, low and none, respectively). (J:110145)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nes (rat) Summary of all recombinase alleles driven by Nes. Comparative matrix view of recombinase activities Alliance rat Nes gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

Original:	J:110145 Imayoshi I, et al., Temporal regulation of Cre recombinase activity in neural stem cells. Genesis. 2006 May;44(5):233-8
All:	5 reference(s)

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