Steap3tm1.1Atel
Targeted Allele Detail
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| Symbol: |
Steap3tm1.1Atel |
| Name: |
STEAP family member 3; targeted mutation 1.1, Adam Telerman |
| MGI ID: |
MGI:4398911 |
| Synonyms: |
TSAP6-, Tsap6del2-3, TSAP6 KO |
| Gene: |
Steap3 Location: Chr1:120154137-120198810 bp, - strand Genetic Position: Chr1, 52.66 cM, cytoband E2
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| Alliance: |
Steap3tm1.1Atel page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:154356
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
C57BL/6
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A 46 bp polynucleotide containing a LoxP site was added 404bp upstream exon 2, and a neomycin resistance gene floxed by two LoxP sites was added 533bp downstream exon 3. Cre-mediated excision of exons 2-3 was achieved upon electroporation of a Cre-recombinase expression vector in the correctly targeted ES clones. Protein was undetected in homozygous mutant mice by Western blot analysis and Immnunohistological staining.
(J:154356)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Steap3 Mutation: |
63 strains or lines available
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| Original: |
J:154356 Lespagnol A, et al., Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice. Cell Death Differ. 2008 Nov;15(11):1723-33 |
| All: |
1 reference(s) |
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Analysis Tools
