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Id2tm1.1(cre/ERT2)Blh
Targeted Allele Detail
Summary
Symbol: Id2tm1.1(cre/ERT2)Blh
Name: inhibitor of DNA binding 2; targeted mutation 1.1, Brigid L Hogan
MGI ID: MGI:4398923
Synonyms: Id2-CreERT2, Id2tm1(CRE/ESR1)Blh
Gene: Id2  Location: Chr12:25143798-25146091 bp, - strand  Genetic Position: Chr12, 8.57 cM, cytoband B
Alliance: Id2tm1.1(cre/ERT2)Blh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:154450
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Id2tm1.1(cre/ERT2)Blh expression driven by 1 gene
 
Mutation details: The targeting vector contained an cre/ERT2 cassette inserted at the translation initiation codon of the Id2 locus, replacing most of exon 1, except for the final 25 nucleotides. The cre cassette was followed by a frt-PGK-neo-frt cassette, which was removed by flp-mediated excision after germline transmission. (J:154450)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Id2 (mouse)
Summary of all recombinase alleles driven by Id2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Id2 Mutation:  21 strains or lines available
References
Original:  J:154450 Rawlins EL, et al., The Id2+ distal tip lung epithelium contains individual multipotent embryonic progenitor cells. Development. 2009 Nov;136(22):3741-5
All:  30 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory