Ptpn23 In situ reporter (knock in) Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:153790 Gingras MC, et al., Expression analysis and essential role of the putative tyrosine phosphatase His-domain-containing protein tyrosine phosphatase (HD-PTP). Int J Dev Biol. 2009;53(7):1069-74
Assay type:	In situ reporter (knock in)
MGI Accession ID:	MGI:4399109
Gene symbol:	Ptpn23
Gene name:	protein tyrosine phosphatase, non-receptor type 23

Reporter:	lacZ
	Direct Detection
Assay notes:	Fixative was 0.2% glutaraldehyde.

Results

Specimen 2A: embryonic day 9.5; Ptpn23^{Gt(YHB130)Byg}/Ptpn23⁺ (more

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Structure	Level	Pattern	Image	Note
TS15: future hindbrain	Strong		2A
TS15: future midbrain	Strong		2A
TS15: neural tube	Strong		2A
TS15: somite	Strong		2A
TS15: optic vesicle	Strong	Regionally restricted	2A	Expression is at the inner side.
TS15: otocyst	Strong	Regionally restricted	2A	Expression is at the inner side.
TS15: telencephalon lateral wall	Strong	Regionally restricted	2A	Expression is in the ventricular layer.
TS15: branchial arch	Weak		2A
TS15: heart	Weak		2A

Specimen 2B: embryonic day 12.5; Ptpn23^{Gt(YHB130)Byg}/Ptpn23⁺ (more

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Structure	Level	Pattern	Image	Note
TS20: common bile duct	Present		2B
TS20: gut	Present		2B
TS20: heart	Present		2B
TS20: lung epithelium	Present		2B
TS20: pancreas	Present		2B
TS20: spinal cord	Present		2B
TS20: stomach	Present		2B
TS20: tongue	Present		2B
TS20: vertebral cartilage condensation	Present		2B
TS20: cranium	Present	Regionally restricted	2B	Expression is in the cartilage primordium of the clivus.
TS20: umbilical artery	Present	Regionally restricted	2B	Expression is in the endothelial layer.
TS20: umbilical vein	Present	Regionally restricted	2B	Expression is in the endothelial layer.
TS20: intraembryonic coelom	Present	Regionally restricted	2B	Expression is in the diaphragm.

Specimen 2C: embryonic day 12.5; Ptpn23^{Gt(YHB130)Byg}/Ptpn23⁺ (more

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Structure	Level	Pattern	Image	Note
TS20: cerebral cortex	Strong		2C
TS20: nasopharynx epithelium	Strong		2C

Specimen 2D: embryonic day 12.5; Ptpn23^{Gt(YHB130)Byg}/Ptpn23⁺ (more

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Structure	Level	Pattern	Image	Note
TS20: pituitary gland	Strong		2D

Specimen 2E: embryonic day 12.5; Ptpn23^{Gt(YHB130)Byg}/Ptpn23⁺ (more

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Structure	Level	Pattern	Image	Note
TS20: vertebral cartilage condensation	Present		2E

Specimen 2F: embryonic day 12.5; Ptpn23^{Gt(YHB130)Byg}/Ptpn23⁺ (more

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Structure	Level	Pattern	Image	Note
TS20: gonad	Strong		2F
TS20: mesonephric tubule	Strong		2F

Specimen 3A: embryonic day 16.5; Ptpn23^{Gt(YHB130)Byg}/Ptpn23⁺ (more

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Structure	Level	Pattern	Image	Note
TS24: cerebral cortex ventricular layer	Strong		3A
TS24: choroid plexus	Strong		3A
TS24: hindbrain	Strong		3A
TS24: inferior vagus ganglion	Strong		3A
TS24: midbrain	Strong		3A
TS24: trigeminal ganglion	Strong		3A
TS24: cerebellum	Strong	Regionally restricted	3A	Expression is in the Purkinje cell layer.
TS24: cochlea	Strong	Regionally restricted	3A	Expression is on the internal side.
TS24: spinal cord	Strong	Regionally restricted	3A	Expression is in the ventral side, absent at the dorsal side.

Specimen 3B: embryonic day 16.5; Ptpn23^{Gt(YHB130)Byg}/Ptpn23⁺ (more

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Structure	Level	Pattern	Image	Note
TS24: spinal cord	Strong	Regionally restricted	3B	Expression is in the ventral side, absent at the dorsal side.

Specimen 3C: embryonic day 16.5; Ptpn23^{Gt(YHB130)Byg}/Ptpn23⁺ (more

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Structure	Level	Pattern	Image	Note
TS24: cardiac muscle tissue	Strong		3C

Specimen 3D: embryonic day 16.5; Ptpn23^{Gt(YHB130)Byg}/Ptpn23⁺ (more

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Structure	Level	Pattern	Image	Note
TS24: cortical renal tubule	Strong		3D
TS24: maturing glomerular tuft	Strong		3D

Specimen 3E: embryonic day 16.5; Ptpn23^{Gt(YHB130)Byg}/Ptpn23⁺ (more

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Structure	Level	Pattern	Image	Note
TS24: lung epithelium	Strong		3E
TS24: trachea epithelium	Strong		3E

Specimen 3F: embryonic day 16.5; Ptpn23^{Gt(YHB130)Byg}/Ptpn23⁺ (more

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Structure	Level	Pattern	Image	Note
TS24: liver parenchyma	Strong		3F

Specimen 3G: embryonic day 16.5; Ptpn23^{Gt(YHB130)Byg}/Ptpn23⁺ (more

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Structure	Level	Pattern	Image	Note
TS24: submandibular gland	Strong	Regionally restricted	3G	Expression is in the acini and ducts.

Specimen 3H: embryonic day 16.5; Ptpn23^{Gt(YHB130)Byg}/Ptpn23⁺ (more

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Structure	Level	Pattern	Image	Note
TS24: hair follicle	Strong	Regionally restricted	3H	Expression is in the inner layer.
TS24: dermis	Strong		3H
TS24: epidermis	Strong		3H

Specimen 4A: postnatal month 6; Ptpn23^{Gt(YHB130)Byg}/Ptpn23⁺ (more

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Structure	Level	Image
TS28: cerebral cortex	Strong	4A
TS28: hypothalamus	Strong	4A
TS28: thalamus	Strong	4A

Specimen 4B: postnatal month 6; Ptpn23^{Gt(YHB130)Byg}/Ptpn23⁺ (more

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Structure	Level	Pattern	Image	Note
TS28: cerebellum Purkinje cell layer	Strong		4B
TS28: cerebellum granule cell layer	Present	Non-Uniform	4B	Uniform and faint staining throughout with some strong staining cells.

Specimen 4C: postnatal month 6; Ptpn23^{Gt(YHB130)Byg}/Ptpn23⁺ (more

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Structure	Level	Pattern	Image	Note
TS28: cortical renal tubule	Very strong		4C
TS28: glomerular tuft	Absent		4C

Specimen 4D: postnatal month 6; Ptpn23^{Gt(YHB130)Byg}/Ptpn23⁺ (more

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Structure	Level	Pattern	Image	Note
TS28: bronchus epithelium	Strong		4D

Specimen 4E: postnatal month 6; Ptpn23^{Gt(YHB130)Byg}/Ptpn23⁺ (more

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Structure	Level	Pattern	Image	Note
TS28: coat hair follicle	Strong		4E
TS28: epidermis	Strong		4E

Specimen 4F: postnatal month 6; Ptpn23^{Gt(YHB130)Byg}/Ptpn23⁺ (more

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Structure	Level	Pattern	Image	Note
TS28: liver parenchyma	Strong		4F

Specimen 4G: postnatal month 6; Ptpn23^{Gt(YHB130)Byg}/Ptpn23⁺ (more

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Structure	Level	Pattern	Image	Note
TS28: stomach epithelium	Strong		4G

Specimen 4H: postnatal month 6; Ptpn23^{Gt(YHB130)Byg}/Ptpn23⁺ (more

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Structure	Level	Pattern	Image	Note
TS28: colon epithelium	Strong		4H

Specimen Not shown: postnatal month 6; Ptpn23^{Gt(YHB130)Byg}/Ptpn23⁺ (more

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Structure	Level	Pattern	Image	Note
TS28: small intestine	Strong
TS28: trachea epithelium	Strong
TS28: heart	Absent
TS28: musculature	Absent
TS28: spleen	Absent

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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