Tg(CD19-cre/ERT2)1Jsv
Transgene Detail
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| Symbol: |
Tg(CD19-cre/ERT2)1Jsv |
| Name: |
transgene insertion 1, J Sjef Verbeek |
| MGI ID: |
MGI:4399751 |
| Synonyms: |
LC-1-hCD19-CreERT2, Tg(CD19-cre/ERT2)1Sjv |
| Transgene: |
Tg(CD19-cre/ERT2)1Jsv Location: unknown
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| Alliance: |
Tg(CD19-cre/ERT2)1Jsv page
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| Transgene Type: |
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Transgenic (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Tg(CD19-cre/ERT2)1Jsv expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Homolog in Mouse |
Note |
| human |
CD19 (930) |
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Mutation details: A DNA fragment encoding cre/ERT2 (cre recombinase fused to the human estrogen receptor with a mutated ligand-binding domain) was inserted downstream of a 6.3-kb fragment of the human CD19 promoter. This construct was inserted into the LC-1 BAC via Red-mediated homologous recombination in E. coli. The recombinant BAC was injected into the pronuclei of fertilized C57BL/6 oocytes. Two founders were generated and one line designated LC-1-hCD19-CreERT2 provided functional cre-mediated recombination. PCR analysis showed that animals carried a single copy of the transgene.
(J:154796)
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Generation of the Tg(CD19-cre/ERT2)1Jsv transgene |
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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CD19
(human)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:154796 Boross P, et al., Highly B lymphocyte-specific tamoxifen inducible transgene expression of CreER T2 by using the LC-1 locus BAC vector. Genesis. 2009 Nov;47(11):729-35 |
| All: |
2 reference(s) |
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Analysis Tools
