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Fzr1tm1.1Stge
Targeted Allele Detail
Summary
Symbol: Fzr1tm1.1Stge
Name: fizzy and cell division cycle 20 related 1; targeted mutation 1.1, Stephen Geley
MGI ID: MGI:4410511
Synonyms: Fzr1fl
Gene: Fzr1  Location: Chr10:81202713-81214204 bp, - strand  Genetic Position: Chr10, 39.72 cM
Alliance: Fzr1tm1.1Stge page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:154779
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn frt flanked neo and kan cassette with a 3' loxP site was inserted upstream of exon 2, and an additional loxP site was inserted downstream of exon 8. Germ line, flp mediated recombination removed the selection cassette leaving exons 2 through 8 floxed. (J:154779)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fzr1 Mutation:  43 strains or lines available
References
Original:  J:154779 Sigl R, et al., Loss of the mammalian APC/C activator FZR1 shortens G1 and lengthens S phase but has little effect on exit from mitosis. J Cell Sci. 2009 Nov 15;122(Pt 22):4208-17
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory