Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(Nes-cre)Wme
Name:	transgene insertion, Werner Muller
MGI ID:	MGI:4412413
Synonyms:	Nestin-Cre
Transgene:	Tg(Nes-cre)Wme  Location: unknown
Alliance:	Tg(Nes-cre)Wme page

Strain of Origin:

(C57BL/6 x CBA)F2

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Nes-cre)Wme expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note Not Specified Nes   Mutation details: The transgenic construct contained a nestin promoter followed by cre recombinase sequence adjoined to a nuclear localization signal. Intron 2 of the nestin gene was included upstream of a polyadenylation signal. While the endogenous nestin promoter is CNS-specific, Southern blot analysis showed the ubiquitous expression of cre in transgenic mice. Variable mosaicism/partial deletion of loxP-flanked alleles occurs before embryonic day 10.5, and it is detectable in all adult organs examined including germ line cells. (J:67926)

Activity:	Tissue activity of this recombinase allele
Driver:	Nes (species not specified) Summary of all recombinase alleles driven by Nes.

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:155064 Lee S, et al., Retinoid signaling and neurogenin2 function are coupled for the specification of spinal motor neurons through a chromatin modifier CBP. Neuron. 2009 Jun 11;62(5):641-54
All:	21 reference(s)