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Rettm1Ddg
Targeted Allele Detail
Summary
Symbol: Rettm1Ddg
Name: ret proto-oncogene; targeted mutation 1, David D Ginty
MGI ID: MGI:4413350
Synonyms: Retf
Gene: Ret  Location: Chr6:118128706-118174679 bp, - strand  Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
Alliance: Rettm1Ddg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:126484
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation details: Exons 14 and 15 and an FRT-flanked neo cassette are flanked by loxP sites. A missense mutation in exon 15 changes valine 805 to alanine. This mutation is silent but sensitizes the protein to chemical inhibition of its kinase activity. (J:126484)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 89 assay results
In Structures Affected by this Mutation: 9 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ret Mutation:  54 strains or lines available
References
Original:  J:126484 Luo W, et al., A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron. 2007 Jun 7;54(5):739-54
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory