About   Help   FAQ
Atoh1tm5.1(cre/PGR)Hzo
Targeted Allele Detail
Summary
Symbol: Atoh1tm5.1(cre/PGR)Hzo
Name: atonal bHLH transcription factor 1; targeted mutation 5.1, Huda Y Zoghbi
MGI ID: MGI:4418334
Synonyms: Atoh1tm5Hzo, Math1cre*PR
Gene: Atoh1  Location: Chr6:64706109-64708229 bp, + strand  Genetic Position: Chr6, 30.03 cM
Alliance: Atoh1tm5.1(cre/PGR)Hzo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155760
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    mifepristone
Mutations:    Insertion, Intragenic deletion
 
Atoh1tm5.1(cre/PGR)Hzo expression driven by 1 gene
 
Mutation details: All coding sequence was replaced by a modified cre/progesterone receptor fusion construct followed by an frt flanked PGK-neomycin selection cassette. The selection cassette was subsequently excised by crossing to mice carrying Gt(ROSA)26Sortm1(FLP1)Dym. In the resulting mice, the inducible cre is under the control of the endogenous gene promoter. (J:155932)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Atoh1 (mouse)
Summary of all recombinase alleles driven by Atoh1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atoh1 Mutation:  37 strains or lines available
References
Original:  J:155760 Rose MF, et al., Math1 is essential for the development of hindbrain neurons critical for perinatal breathing. Neuron. 2009 Nov 12;64(3):341-54
All:  10 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory