Kat6a<tm2.2Avo> Targeted Allele Detail MGI Mouse (MGI:4418468)

Kat6a^tm2.2Avo
Targeted Allele Detail

Summary

Symbol:	Kat6a^tm2.2Avo
Name:	K(lysine) acetyltransferase 6A; targeted mutation 2.2, Anne K Voss
MGI ID:	MGI:4418468
Synonyms:	Moz^-
Gene:	Kat6a Location: Chr8:23349551-23433275 bp, + strand Genetic Position: Chr8, 11.42 cM
Alliance:	Kat6a^tm2.2Avo page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:155755
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1^a

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Exons 3 to 7 were flanked by loxP sites (after removal of an Frt-flanked "Pgk1-neomycinphotransferase" selection cassette). Exons 3 to 7 were deleted upon cre mediated recombination. (J:155755)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	64 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Kat6a^tm2.2Avo

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Kat6a Mutation:	69 strains or lines available

References

Original:	J:155755 Voss AK, et al., Moz and retinoic acid coordinately regulate H3K9 acetylation, Hox gene expression, and segment identity. Dev Cell. 2009 Nov;17(5):674-86
All:	7 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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