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Ehmt2tm1.1Tara
Targeted Allele Detail
Summary
Symbol: Ehmt2tm1.1Tara
Name: euchromatic histone lysine N-methyltransferase 2; targeted mutation 1.1, Alexander Tarakhovsky
MGI ID: MGI:4418499
Synonyms: G9af
Gene: Ehmt2  Location: Chr17:35117445-35133028 bp, + strand  Genetic Position: Chr17, 18.45 cM
Alliance: Ehmt2tm1.1Tara page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155931
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: Exons 23 and 24 were floxed and an FRT-flanked neo cassette inserted into intron 24 via homologous recombination. The selection cassette was then removed by flp mediated recombination. Cre-mediated recombination results in out-of-frame splicing and nonsense mediated decay of the mutant transcript. (J:155931)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ehmt2 Mutation:  57 strains or lines available
References
Original:  J:155931 Sampath SC, et al., Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly. Mol Cell. 2007 Aug 17;27(4):596-608
All:  17 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory