Tg(GFAP-cre/ERT2)1Fki
Transgene Detail
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| Symbol: |
Tg(GFAP-cre/ERT2)1Fki |
| Name: |
transgene insertion 1, Frank Kirchhoff |
| MGI ID: |
MGI:4418665 |
| Synonyms: |
GFAP-CreERT2, TgN(GFAP-CreERT2)GCTF-Fki |
| Transgene: |
Tg(GFAP-cre/ERT2)1Fki Location: unknown
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| Alliance: |
Tg(GFAP-cre/ERT2)1Fki page
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| Transgene Type: |
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Transgenic (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Tg(GFAP-cre/ERT2)1Fki expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Homolog in Mouse |
Note |
| human |
GFAP (2670) |
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Mutation details: The construct contains the human glial fibrillary acidic protein (GFAP), a tripartite intron composed of an adenovirus splice donor and immunoglobulin G splice acceptor site, the open reading frame of cre/ERT2 (cre fused to an improved mutant human estrogen receptor), and a human growth hormone polyA site. The linearized 5.3kb fragment was injected into FVB/N fertilized oocytes. Two lines were found to express cre protein and one line designated 1 (called GCTF in J:156009) was analyzed further.
(J:156009)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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GFAP
(human)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:156009 Hirrlinger PG, et al., Temporal control of gene recombination in astrocytes by transgenic expression of the tamoxifen-inducible DNA recombinase variant CreERT2. Glia. 2006 Jul;54(1):11-20 |
| All: |
43 reference(s) |
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Analysis Tools
