Coro1c<tm1a(KOMP)Wtsi> Targeted Allele Detail MGI Mouse (MGI:4419168)

Coro1c^{tm1a(KOMP)Wtsi}
Targeted Allele Detail

Summary

Symbol:	Coro1c^{tm1a(KOMP)Wtsi}
Name:	coronin, actin binding protein 1C; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID:	MGI:4419168
Synonyms:	CRN2 KO
Gene:	Coro1c Location: Chr5:113980500-114046767 bp, - strand Genetic Position: Chr5, 55.64 cM, cytoband F
Alliance:	Coro1c^{tm1a(KOMP)Wtsi} page
IMPC:	Coro1c gene page

Mutation
origin

Mutant Cell Lines:	EPD0343_2_A01, EPD0343_2_A02, EPD0343_2_A04, EPD0343_2_A06, EPD0343_2_A10, EPD0343_2_A11, EPD0343_2_B01, EPD0343_2_B02, EPD0343_2_B04, EPD0343_2_B05, EPD0343_2_B06, EPD0343_2_B07, EPD0343_2_B08, EPD0343_2_B09, EPD0343_2_B10, EPD0343_2_B11, EPD0343_2_C01, EPD0343_2_C04, EPD0343_2_C05, EPD0343_2_C08, EPD0343_2_C09, EPD0343_2_C11, EPD0343_2_D01, EPD0343_2_D02, EPD0343_2_D04, EPD0343_2_D06, EPD0343_2_D12, EPD0343_2_E01, EPD0343_2_E02, EPD0343_2_E06, EPD0343_2_E08, EPD0343_2_E09, EPD0343_2_E10, EPD0343_2_E11, EPD0343_2_E12, EPD0343_2_F01, EPD0343_2_F08, EPD0343_2_F09, EPD0343_2_F10, EPD0343_2_G04, EPD0343_2_G07, EPD0343_2_G09, EPD0343_2_G10, EPD0343_2_H02, EPD0343_2_H04, EPD0343_2_H06, EPD0343_2_H07, EPD0343_2_H08, EPD0343_2_H09, EPD0343_2_H10, EPD0343_2_H12
Germline Transmission:	Earliest citation of germline transmission: J:175295
Parent Cell Line:	JM8A1.N3 (ES Cell)
Strain of Origin:	C57BL/6N-A^tm1Brd
Project Collection:	KOMP-CSD

Mutation
description

Allele Type:		Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:		Insertion Vector: L1L2_Bact_P
		Mutation details: The L1L2_Bact_P cassette was inserted at position 113988438 of Chromosome 5 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 113989346. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 1 line available
Carrying any Coro1c Mutation:	69 strains or lines available

References

Original:	J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:	8 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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