Rec114<tm1(KOMP)Wtsi> Targeted Allele Detail MGI Mouse (MGI:4419253)

Rec114^{tm1(KOMP)Wtsi}
Targeted Allele Detail

Summary

Symbol:	Rec114^{tm1(KOMP)Wtsi}
Name:	REC114 meiotic recombination protein; targeted mutation 1, Wellcome Trust Sanger Institute
MGI ID:	MGI:4419253
Synonyms:	2410076I21Rik^{tm1(KOMP)Wtsi}, Rec114^-
Gene:	Rec114 Location: Chr9:58560133-58651247 bp, - strand Genetic Position: Chr9, 31.79 cM, cytoband C
Alliance:	Rec114^{tm1(KOMP)Wtsi} page
IMPC:	Rec114 gene page

Mutation
origin

Mutant Cell Lines:	EPD0392_4_D08, EPD0392_4_E07, EPD0392_4_E08, EPD0392_4_F06, EPD0392_4_F08, EPD0392_4_G06, EPD0392_4_G08, EPD0392_4_H05, EPD0392_4_H06, EPD0392_4_H07
Germline Transmission:	Earliest citation of germline transmission: J:271216
Parent Cell Line:	JM8A3.N1 (ES Cell)
Strain of Origin:	C57BL/6N-A^tm1Brd
Project Collection:	KOMP-CSD

Mutation
description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutations:		Insertion, Intragenic deletion Vector: L1L2_Bact_P
		Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 5762 starting at position 58567450 and ending at position 58573212 of Chromosome 9 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. (J:148605, J:173534, J:271216)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 1 line available
Carrying any Rec114 Mutation:	14 strains or lines available

Notes

Cell line EPD0392_4_D08 was successfully used to make chimeric mice. Germline transmission was accomplished. J:271216

References

Original:	J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:	4 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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