Tg(Aqp4-cre/ERT2)55-27Fwp
Transgene Detail
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| Symbol: |
Tg(Aqp4-cre/ERT2)55-27Fwp |
| Name: |
transgene insertion 55-27, Frank W Pfrieger |
| MGI ID: |
MGI:4420275 |
| Synonyms: |
Tg(Aqp4-CreERT2)5527 |
| Transgene: |
Tg(Aqp4-cre/ERT2)55-27Fwp Location: unknown
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| Alliance: |
Tg(Aqp4-cre/ERT2)55-27Fwp page
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| Transgene Type: |
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Transgenic (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Tg(Aqp4-cre/ERT2)55-27Fwp expression driven by
1 gene
Transgene expression driven by:
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Mutation details: The creERT2 expression cassette, preceded by a rabbit beta-globin DNA encompassing intron 2 (beta-globin intervening sequences [bGIVS]) and followed by the SV40 polyA signal and a PGK/Tn5-driven neomycin resistance cassette flanked by FRT sites (neo) was inserted by homologous recombination at the transcription initiation site of the Aqp4 gene located in BAC RP23-189N2. The linearized vector was injected into pronuclei of fertilized FVB/N eggs. In line 55-27, cre/ERT2 mRNA was detected in similar brain regions as Aqp4 but at much lower concentrations.
(J:156087)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Aqp4
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:156087 Slezak M, et al., Transgenic mice for conditional gene manipulation in astroglial cells. Glia. 2007 Nov 15;55(15):1565-76 |
| All: |
1 reference(s) |
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Analysis Tools
