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Dmrt3tm1Hgc
Targeted Allele Detail
Summary
Symbol: Dmrt3tm1Hgc
Name: doublesex and mab-3 related transcription factor 3; targeted mutation 1, Edward M Rubin
MGI ID: MGI:4420993
Gene: Dmrt3  Location: Chr19:25587665-25601285 bp, + strand  Genetic Position: Chr19, 20.5 cM
Alliance: Dmrt3tm1Hgc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:128347
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation details: The mutant allele was generated by deleting a sequence covering exon 1, which includes the start codon and the DM binding domain of the encoded protein. A loxP-flanked neomycin selection cassette replaced a part of exon 1, and the cassette was subsequently removed via cre-mediated recombination. (J:187218)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dmrt3 Mutation:  12 strains or lines available
References
Original:  J:128347 Ahituv N, et al., Deletion of ultraconserved elements yields viable mice. PLoS Biol. 2007 Sep;5(9):e234
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory