Klf5tm2.1Rng
Targeted Allele Detail
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| Symbol: |
Klf5tm2.1Rng |
| Name: |
Kruppel-like transcription factor 5; targeted mutation 2.1, Ryozo Nagai |
| MGI ID: |
MGI:4421792 |
| Synonyms: |
Klf5fl |
| Gene: |
Klf5 Location: Chr14:99536127-99550848 bp, + strand Genetic Position: Chr14, 49.43 cM, cytoband E2.1
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| Alliance: |
Klf5tm2.1Rng page
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Fibroblast-specific deletion of Klf5 attenuates cardiac hypertrophy and fibrosis after TAC in Klf5tm2.1Rng/Klf5tm2.1Rng Tg(Postn-cre)1Sjc mice
Show the 3 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:156696
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Conditional ready, No functional change) |
| Mutation: |
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Insertion
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Mutation details: A loxP site was inserted upstream of exon 2 and a neo cassette flanked by loxP and frt sites was inserted downstream of exon 2. Flp mediated recombination removed the neo cassette leaving exon 2 floxed.
(J:156696)
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Generation of the Klf5tm2.1Rng allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Klf5 Mutation: |
37 strains or lines available
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| Original: |
J:156696 Takeda N, et al., Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload. J Clin Invest. 2010 Jan;120(1):254-65 |
| All: |
15 reference(s) |
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Analysis Tools
