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Pvalbtm1.1(cre)Aibs
Targeted Allele Detail
Summary
Symbol: Pvalbtm1.1(cre)Aibs
Name: parvalbumin; targeted mutation 1.1, Allen Institute for Brain Science
MGI ID: MGI:4421793
Synonyms: Pvalb-2A-Cre, Pvalbtm1(cre)Aibs, PvCre(Aibs)
Gene: Pvalb  Location: Chr15:78075314-78090600 bp, - strand  Genetic Position: Chr15, 36.93 cM, cytoband E
Alliance: Pvalbtm1.1(cre)Aibs page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155793
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Pvalbtm1.1(cre)Aibs expression driven by 1 gene
 
Mutation details: A targeting vector was designed to insert a viral 2A oligopeptide that mediates ribosomal skipping and a Cre recombinase gene immediately downstream of the parvalbumin translational STOP codon. The targeting vector contained, from 5' to 3', a 3 amino acid linker sequence, an frt3 site, a viral 2A oligopeptide, a Cre recombinase gene, a translational STOP sequence (TAA codon), an attB site, a PGK-Neo-polyA cassette, an frt5 site, an RNA splice acceptor, the 3' portion of the hygromycin gene with SV40 polyA signal, and attP site. This construct was electroporated into (129S6/SvEvTac x C57BL/6)F1-derived G4 embryonic stem (ES) cells. (J:155793)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pvalb (mouse)
Summary of all recombinase alleles driven by Pvalb.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pvalb Mutation:  29 strains or lines available
References
Original:  J:155793 Madisen L, et al., A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci. 2010 Jan;13(1):133-40
All:  48 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory