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Rfx6tm1.1(EGFP/cre)Mger
Targeted Allele Detail
Summary
Symbol: Rfx6tm1.1(EGFP/cre)Mger
Name: regulatory factor X, 6; targeted mutation 1.1, Michael S German
MGI ID: MGI:4429702
Synonyms: Rfx6eGFPcre
Gene: Rfx6  Location: Chr10:51553856-51606525 bp, + strand  Genetic Position: Chr10, 25.74 cM
Alliance: Rfx6tm1.1(EGFP/cre)Mger page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:156925
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Rfx6tm1.1(EGFP/cre)Mger expression driven by 1 gene
 
Mutation details: Recombineering methods were used to modify a BAC containing the Rfx6 gene and generate the targeting construct. Homologous recombination in ES cells resulted in the first 5 exons being replaced by and EFGP/cre fusion gene followed by an FRT-flanked neo cassette. The neo was subsequently removed by crossing mice carrying the disrupted allele with Actb-Flp mice. (J:156925)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Rfx6 (mouse)
Summary of all recombinase alleles driven by Rfx6.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rfx6 Mutation:  52 strains or lines available
References
Original:  J:156925 Smith SB, et al., Rfx6 directs islet formation and insulin production in mice and humans. Nature. 2010 Feb 11;463(7282):775-80
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory