Fgfr2<tm2Ewj> Targeted Allele Detail MGI Mouse (MGI:4430185)

Fgfr2^tm2Ewj
Targeted Allele Detail

Summary

Symbol:	Fgfr2^tm2Ewj
Name:	fibroblast growth factor receptor 2; targeted mutation 2, Ethylin Wang Jabs
MGI ID:	MGI:4430185
Synonyms:	Fgfr2^P253Rneo
Gene:	Fgfr2 Location: Chr7:129764181-129868538 bp, - strand Genetic Position: Chr7, 73.19 cM
Alliance:	Fgfr2^tm2Ewj page

Skeletal abnormalities in Fgfr2^tm2Ewj/Fgfr2⁺ Tg(EIIa-cre)C5379Lmgd/0 mice

Show the 8 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:156940
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Humanized sequence)
Mutations:		Insertion, Single point mutation
		Mutation details: A C to G transversion results in the amino acid substitution of arginine for proline at position 253 (P253R). A floxed neo cassette was used for selection purposes. (J:158773)

Generation of the Fgfr2^tm2Ewj allele

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Fgfr2 Mutation:	90 strains or lines available

References

Original:	J:156940 Aldridge K, et al., Brain phenotypes in two FGFR2 mouse models for Apert syndrome. Dev Dyn. 2010 Jan 13;239(3):987-997
All:	7 reference(s)

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