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Foxl2tm4(cre)Tre
Targeted Allele Detail
Summary
Symbol: Foxl2tm4(cre)Tre
Name: forkhead box L2; targeted mutation 4, Mathias Treier
MGI ID: MGI:4430207
Synonyms: Foxl2Cre
Gene: Foxl2  Location: Chr9:98837495-98840601 bp, + strand  Genetic Position: Chr9, 51.41 cM, cytoband E4
Alliance: Foxl2tm4(cre)Tre page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:157008
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Foxl2tm4(cre)Tre expression driven by 1 gene
 
Mutation details: A 1.6 kb fragment encoding cre recombinase followed by the rabbit beta-globin polyadenylation signal was used to generate a targeting vector that replaced the translational start site of Foxl2 with the cre-ATG start codon by homologous recombination. The targeting vector contained a self-excising neo cassette (ACN cassette) and a diphtheria toxin-negative selection cassette (DTA). The ACN cassette was excised during passage through the male germline. (J:157008)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Foxl2 (mouse)
Summary of all recombinase alleles driven by Foxl2.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxl2 Mutation:  15 strains or lines available
References
Original:  J:157008 Uhlenhaut NH, et al., Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. Cell. 2009 Dec 11;139(6):1130-42
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory