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Scn10atm1Lex
Targeted Allele Detail
Summary
Symbol: Scn10atm1Lex
Name: sodium channel, voltage-gated, type X, alpha; targeted mutation 1, Lexicon Genetics
MGI ID: MGI:4430300
Gene: Scn10a  Location: Chr9:119437522-119548388 bp, - strand  Genetic Position: Chr9, 71.33 cM, cytoband distal
Alliance: Scn10atm1Lex page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:157066
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exons 8-10 were replaced with a IRES-LacZ Neo cassette by homologous recombination. Expression was abolished in the dorsal root ganglia (DRG) and spinal cord as determined by quantitative RT-PCR. (J:157066)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Scn10a Mutation:  102 strains or lines available
References
Original:  J:157066 Hillsley K, et al., Dissecting the role of sodium currents in visceral sensory neurons in a model of chronic hyperexcitability using Nav1.8 and Nav1.9 null mice. J Physiol. 2006 Oct 1;576(Pt 1):257-67
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory