Grhl3<tm1(cre)Cgh> Targeted Allele Detail MGI Mouse (MGI:4430902)

Grhl3^tm1(cre)Cgh
Targeted Allele Detail

Summary

Symbol:	Grhl3^tm1(cre)Cgh
Name:	grainyhead like transcription factor 3; targeted mutation 1, Shaun R Coughlin
MGI ID:	MGI:4430902
Synonyms:	Grhl3^cre
Gene:	Grhl3 Location: Chr4:135269199-135300941 bp, - strand Genetic Position: Chr4, 67.76 cM
Alliance:	Grhl3^tm1(cre)Cgh page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:157446
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:

Targeted (Recombinase)

Mutation:

Insertion

Grhl3^tm1(cre)Cgh expression driven by 1 gene

Mutation details: Exon 1 was disrupted by the insertion of a cassette containing a cre, IRES, nuclear localization signal, and lacZ in frame with the ATG start site. An frt flanked neomycin cassette was inserted following lacZ. Chimeric males were crossed with females expressing Flp recombinase on a C57BL/6 background in order to excise the neo selection cassette. (J:157446)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Grhl3 (mouse) Summary of all recombinase alleles driven by Grhl3. Comparative matrix view of recombinase activities Alliance mouse Grhl3 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Grhl3 Mutation:	53 strains or lines available

References

Original:	J:157446 Camerer E, et al., Local protease signaling contributes to neural tube closure in the mouse embryo. Dev Cell. 2010 Jan 19;18(1):25-38
All:	21 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24