Is(14)2Rdf Targeted Allele Detail MGI Mouse (MGI:4437013)

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Is(14)2Rdf
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Is(14)2Rdf
Name:	insertion, Chr 14, Riccardo Dalla-Favera 2
MGI ID:	MGI:4437013
Gene:	Is(14)2Rdf Location: unknown Genetic Position: Chr14, Syntenic

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:156946
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: LoxP and FRT sites as well as a PGK promoter and Hygro cassette were place about 5 kb telomeric to the alternative exon 1 of Dleu2 by homologous recombination. The targeting was done in ES cells carrying Is(14)1Rdf. The two constructs are in cis configuration. (J:156946)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available Cell Lines: 0 lines available
Carrying any Is(14)2Rdf Mutation:	3 strains or lines available

References

Original:	J:156946 Klein U, et al., The DLEU2/miR-15a/16-1 Cluster Controls B Cell Proliferation and Its Deletion Leads to Chronic Lymphocytic Leukemia. Cancer Cell. 2010 Jan 19;17(1):28-40
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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