Ret<tm2(cre/ERT2)Ddg> Targeted Allele Detail MGI Mouse (MGI:4437245)

Ret^{tm2(cre/ERT2)Ddg}
Targeted Allele Detail

Summary

Symbol:	Ret^{tm2(cre/ERT2)Ddg}
Name:	ret proto-oncogene; targeted mutation 2, David D Ginty
MGI ID:	MGI:4437245
Synonyms:	Ret^CreER, Ret-CreERT2, Ret^CreERT2, Ret^ERT2
Gene:	Ret Location: Chr6:118128706-118174679 bp, - strand Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
Alliance:	Ret^{tm2(cre/ERT2)Ddg} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:157722
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:

Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Mutations:

Insertion, Intragenic deletion

Ret^{tm2(cre/ERT2)Ddg} expression driven by 1 gene

Mutation details: The first exon of the Ret gene was targeted for homologous recombination. A sequence encoding inducible cre/ERT2, followed by a loxP-flanked AC-Cre Tn5-neo self-excising cassette, was targeted to exon 1 of Ret in ES cells. Following excision of the floxed neo cassette, a line of knockin mice expressing cre/ERT2 was generated. Spatial and temporal expression patterns of the inducible cre recapitulated Ret expression. (J:157722)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ret (mouse) Summary of all recombinase alleles driven by Ret. Comparative matrix view of recombinase activities Alliance mouse Ret gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Ret Mutation:	54 strains or lines available

References

Original:	J:157722 Luo W, et al., Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling. Neuron. 2009 Dec 24;64(6):841-56
All:	41 reference(s)

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