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Lgi4tm1Sjm
Targeted Allele Detail
Summary
Symbol: Lgi4tm1Sjm
Name: leucine-rich repeat LGI family, member 4; targeted mutation 1, Sean J Morrison
MGI ID: MGI:4439269
Synonyms: Lgi4LacZ
Gene: Lgi4  Location: Chr7:30758767-30770360 bp, + strand  Genetic Position: Chr7, 19.29 cM
Alliance: Lgi4tm1Sjm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:166449
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The lacZ gene has replaced the first three exons of the endogenous gene so that beta-galactosidase is expressed under control of the endogenous regulatory elements. Flp-mediated recombination removed the neo cassette used for selection. (J:166449)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 81 assay results
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lgi4 Mutation:  33 strains or lines available
Notes
ES Cell Line = Bruce4.G9, a subline of Bruce 4.
References
Original:  J:166449 Nishino J, et al., Lgi4 promotes the proliferation and differentiation of glial lineage cells throughout the developing peripheral nervous system. J Neurosci. 2010 Nov 10;30(45):15228-40
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory