Nkx6-2<tm2(cre)Ercs> Targeted Allele Detail MGI Mouse (MGI:4440471)

Nkx6-2^tm2(cre)Ercs
Targeted Allele Detail

Summary

Symbol:	Nkx6-2^tm2(cre)Ercs
Name:	NK6 homeobox 2; targeted mutation 2, Johan Ericson
MGI ID:	MGI:4440471
Synonyms:	Nkx6.2^cre, Nkx6.2-Cre
Gene:	Nkx6-2 Location: Chr7:139159292-139162713 bp, - strand Genetic Position: Chr7, 84.57 cM
Alliance:	Nkx6-2^tm2(cre)Ercs page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:131770
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:

Targeted (Recombinase)

Mutations:

Insertion, Intragenic deletion

Nkx6-2^tm2(cre)Ercs expression driven by 1 gene

Mutation details: The targeting vector used to generate the Nkx6-2^tm1Ercs allele was modified by replacing the lacZ/PGKneo cassette with a cre/PGKneo cassette. The same strategy as described in J:71607 was followed to generate this Nkx6-2 mutant allele using the modified targeting vector. (J:131770)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nkx6-2 (mouse) Summary of all recombinase alleles driven by Nkx6-2. Alliance mouse Nkx6-2 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Nkx6-2 Mutation:	17 strains or lines available

References

Original:	J:131770 Baudet C, et al., Retrograde signaling onto Ret during motor nerve terminal maturation. J Neurosci. 2008 Jan 23;28(4):963-75
All:	5 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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