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Bhlhe22tm3.1(cre)Meg
Targeted Allele Detail
Summary
Symbol: Bhlhe22tm3.1(cre)Meg
Name: basic helix-loop-helix family, member e22; targeted mutation 3.1, Michael E Greenberg
MGI ID: MGI:4440745
Synonyms: B5-cre, Bhlhb5-cre, Bhlhe22-Cre
Gene: Bhlhe22  Location: Chr3:18108489-18111678 bp, + strand  Genetic Position: Chr3, 4.98 cM, cytoband A2
Alliance: Bhlhe22tm3.1(cre)Meg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:158273
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Bhlhe22tm3.1(cre)Meg expression driven by 1 gene
 
Mutation details: The coding region of the Bhlhe22 gene was replaced by the coding sequence of cre recombinase and a loxP flanked neo selection cassette via homologous recombination in ES cells. The neo was removed in the ES cells by cre-mediated excision. (J:158273)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Bhlhe22 (mouse)
Summary of all recombinase alleles driven by Bhlhe22.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bhlhe22 Mutation:  12 strains or lines available
References
Original:  J:158273 Ross SE, et al., Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice. Neuron. 2010 Mar 25;65(6):886-98
All:  13 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory