Sp2tm1Sus
Targeted Allele Detail
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| Symbol: |
Sp2tm1Sus |
| Name: |
Sp2 transcription factor; targeted mutation 1, Guntram Suske |
| MGI ID: |
MGI:4441277 |
| Synonyms: |
Sp2lzn |
| Gene: |
Sp2 Location: Chr11:96844167-96873785 bp, - strand Genetic Position: Chr11, 60.17 cM, cytoband D
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| Alliance: |
Sp2tm1Sus page
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Impaired development of Sp2tm1Sus/Sp2tm1Sus embryos
Show the 1 phenotype image(s) involving this allele.
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| Allele Type: |
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Targeted (Conditional ready, No functional change) |
| Mutation: |
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Insertion
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Mutation details: Two loxP sites were inserted to flank exon 3 of the gene, followed by an SA-IRES-lacZ-neo-SVpA cassette and a third loxP site after the cassette in intron 3. Northern blot analyses revealed aberrant mRNA expression. Immunoblot analysis showed the absence of the full-length protein; a truncated N-terminal fragment was below the detection limit.
(J:158671)
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Generation of the Sp2tm1Sus allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Sp2 Mutation: |
151 strains or lines available
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| Original: |
J:158671 Baur F, et al., Specificity protein 2 (Sp2) is essential for mouse development and autonomous proliferation of mouse embryonic fibroblasts. PLoS One. 2010;5(3):e9587 |
| All: |
1 reference(s) |
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Analysis Tools
