Sp2<tm1.2Sus> Targeted Allele Detail MGI Mouse (MGI:4441280)

Sp2^tm1.2Sus
Targeted Allele Detail

Summary

Symbol:	Sp2^tm1.2Sus
Name:	Sp2 transcription factor; targeted mutation 1.2, Guntram Suske
MGI ID:	MGI:4441280
Synonyms:	Sp2null
Gene:	Sp2 Location: Chr11:96844167-96873785 bp, - strand Genetic Position: Chr11, 60.17 cM, cytoband D
Alliance:	Sp2^tm1.2Sus page

Small size, failure of embryo turning, and open cranial neural tube in Sp2^tm1.2Sus/Sp2^tm1.2Sus embryos

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:158671
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	(C57BL/6 x 129P2/OlaHsd)F1

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Two loxP sites were inserted to flank exon 3 of the gene, followed by an SA-IRES-lacZ-neo-SVpA cassette and a third loxP site after the cassette in intron 3. The flanked exon 3 and SA-IRES-lacZ-neo-SVpA cassette were deleted by Cre mediated recombination. (J:158671)

Generation of the Sp2^tm1.2Sus allele

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Sp2 Mutation:	151 strains or lines available

References

Original:	J:158671 Baur F, et al., Specificity protein 2 (Sp2) is essential for mouse development and autonomous proliferation of mouse embryonic fibroblasts. PLoS One. 2010;5(3):e9587
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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