Il7rtm1.1(icre)Hrr
Targeted Allele Detail
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| Symbol: |
Il7rtm1.1(icre)Hrr |
| Name: |
interleukin 7 receptor; targeted mutation 1.1, Hans-Reimer Rodewald |
| MGI ID: |
MGI:4441349 |
| Synonyms: |
CD127-Cre-Tg, Il7rCre |
| Gene: |
Il7r Location: Chr15:9505874-9530262 bp, - strand Genetic Position: Chr15, 4.16 cM
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| Alliance: |
Il7rtm1.1(icre)Hrr page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:158903
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| Parent Cell Line: |
E14.1 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Recombinase) |
| Mutation: |
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Insertion
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Il7rtm1.1(icre)Hrr expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Il7r (MGI:96562) |
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Mutation details: The targeting construct consisted, from 5' to 3', of a homology arm with sequence upstream of the Il7r ATG start site, a splice donor site, an intron and a splice acceptor site from the rabbit b-globin gene, the coding sequence of codon-improved cre (icre), a poly-adenylation signal from the rabbit b-globin gene, an FRT-flanked neomycin resistance gene, a 3' homology sequence and a diphtheria toxin subunit A negative selection sequence. Homologous recombination was carried out in E14.1 ES cells. To avoid potential impact of the Neo resistance gene with its enhancer and promoter sequences on iCre expression, the neo cassette was removed from the targeted locus by transient expression of Flp-recombinase, leaving only a single FRT-site in the genome.
(J:158903)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Il7r
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Il7r Mutation: |
31 strains or lines available
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| Original: |
J:158903 Schlenner SM, et al., Fate mapping reveals separate origins of T cells and myeloid lineages in the thymus. Immunity. 2010 Mar 26;32(3):426-36 |
| All: |
57 reference(s) |
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Analysis Tools
