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Tg(S100b-cre)20Ito
Transgene Detail
Summary
Symbol: Tg(S100b-cre)20Ito
Name: transgene insertion 20, Shigeyoshi Itohara
MGI ID: MGI:4441370
Synonyms: S100b-Cre, Tg20
Transgene: Tg(S100b-cre)20Ito  Location: unknown  
Alliance: Tg(S100b-cre)20Ito page
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(S100b-cre)20Ito expression driven by 1 gene
 
Mutation detailsThe nls-cre (nuclear localization sequence-cre) polyA cassette was inserted immediately upstream of the translation initiation site in an 11.7 kb S100b promoter-containing genomic sequence (-5387/+6357). This targeting construct was microinjected into pronuclei of fertilized C57BL/6 embryos. Six lines were generated, four of which showed similar recombination patterns in the adult brain when crossed to transgenic reporter mice. Line 20 (Tg20) displayed no recombination in the heart, lung, kidney, spleen, skeletal muscle, and blood vessel and partial recombination in skin and liver. (J:159160)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: S100b (species not specified)
Summary of all recombinase alleles driven by S100b.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:159160 Tanaka M, et al., Lack of Connexin43-mediated bergmann glial gap junctional coupling does not affect cerebellar long-term depression, motor coordination, or eyeblink conditioning. Front Behav Neurosci. 2008;2:1
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory