About   Help   FAQ
Syktm1(cre)Fkfr
Targeted Allele Detail
Summary
Symbol: Syktm1(cre)Fkfr
Name: spleen tyrosine kinase; targeted mutation 1, Friedemann Kiefer
MGI ID: MGI:4442916
Synonyms: Syk-Creneo
Gene: Syk  Location: Chr13:52737209-52802828 bp, + strand  Genetic Position: Chr13, 27.41 cM, cytoband B-C2
Alliance: Syktm1(cre)Fkfr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159112
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Syktm1(cre)Fkfr expression driven by 1 gene
 
Mutation details: A targeting vector was assembled by Red/ET recombination in which cre recombinase was driven by the Sykb regulatory elements. An FRT-flanked Pgk-neomycin selection cassette was included in the construct. The construct was electroporated into R1 ES cells. Correctly recombined clones were injected into C57BL/6 blastocysts to generate chimeras. (J:159112)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Syk (mouse)
Summary of all recombinase alleles driven by Syk.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Syk Mutation:  42 strains or lines available
References
Original:  J:159112 Bohmer R, et al., Regulation of developmental lymphangiogenesis by Syk(+) leukocytes. Dev Cell. 2010 Mar 16;18(3):437-49
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/03/2024
MGI 6.24 		The Jackson Laboratory