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Syktm1(cre)Fkfr
Targeted Allele Detail
Summary
Symbol: Syktm1(cre)Fkfr
Name: spleen tyrosine kinase; targeted mutation 1, Friedemann Kiefer
MGI ID: MGI:4442916
Synonyms: Syk-Creneo
Gene: Syk  Location: Chr13:52737209-52802828 bp, + strand  Genetic Position: Chr13, 27.41 cM, cytoband B-C2
Alliance: Syktm1(cre)Fkfr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159112
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Syktm1(cre)Fkfr expression driven by 1 gene
 
Mutation details: A targeting vector was assembled by Red/ET recombination in which cre recombinase was driven by the Sykb regulatory elements. An FRT-flanked Pgk-neomycin selection cassette was included in the construct. The construct was electroporated into R1 ES cells. Correctly recombined clones were injected into C57BL/6 blastocysts to generate chimeras. (J:159112)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Syk (mouse)
Summary of all recombinase alleles driven by Syk.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Syk Mutation:  42 strains or lines available
References
Original:  J:159112 Bohmer R, et al., Regulation of developmental lymphangiogenesis by Syk(+) leukocytes. Dev Cell. 2010 Mar 16;18(3):437-49
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory