Gt(ROSA)26Sortm1.1(rtTA,tetO-cre)Bkmn
Targeted Allele Detail
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| Symbol: |
Gt(ROSA)26Sortm1.1(rtTA,tetO-cre)Bkmn |
| Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Cristina M Backman |
| MGI ID: |
MGI:4443293 |
| Synonyms: |
R26rtTA-TRECre |
| Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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| Alliance: |
Gt(ROSA)26Sortm1.1(rtTA,tetO-cre)Bkmn page
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| Allele Type: |
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Targeted (Inducible, Recombinase, Transactivator) |
| Inducer: |
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doxycycline/tetracycline |
| Mutation: |
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Insertion
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Gt(ROSA)26Sortm1.1(rtTA,tetO-cre)Bkmn expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| bacteria |
tetO |
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Mutation details: A targeting vector was generated that contained 5 + 3' homology arms to the first intron of the Gt(ROSA)26Sor locus, a cassette containing a splice acceptor, the improved rtTA-M2 element followed by a human TP53 intron and in opposite orientation, the tet-response element TRE-tight promoter driving a cre coding sequence (tetO-cre). The vector also contained an FRT-flanked neo selection cassette. Homologous recombination was done in R1 ES cells. Germline mice were produced and subsequently crossed to Flpe deleter mice to delete the neo cassette.
(J:159515)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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tetO
(bacteria)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Gt(ROSA)26Sor Mutation: |
993 strains or lines available
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| Original: |
J:159515 Backman CM, et al., Generalized tetracycline induced Cre recombinase expression through the ROSA26 locus of recombinant mice. J Neurosci Methods. 2009 Jan 15;176(1):16-23 |
| All: |
2 reference(s) |
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Analysis Tools
