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Tra2btm1.1Bwir
Targeted Allele Detail
Summary
Symbol: Tra2btm1.1Bwir
Name: transformer 2 beta; targeted mutation 1.1, Brunhilde Wirth
MGI ID: MGI:4450919
Synonyms: Sfrs10fl
Gene: Tra2b  Location: Chr16:22063302-22084755 bp, - strand  Genetic Position: Chr16, 13.18 cM
Alliance: Tra2btm1.1Bwir page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159448
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: A single loxP site and an frt flanked neomycin resistance cassette were inserted upstream of exon 4 and a second loxP site was inserted downstream of the exon. Neomycin was excised in mice by crossing to the FLP deleter line, Tg(ACTFLPe)9205Dym. Deletion of exon 4 by cre mediated excision will result in a frameshift and a premature stop codon in exon 5. (J:159448)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tra2b Mutation:  22 strains or lines available
References
Original:  J:159448 Mende Y, et al., Deficiency of the splicing factor Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn splicing. Hum Mol Genet. 2010 Jun 1;19(11):2154-67
All:  9 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
MGI 6.24 		The Jackson Laboratory