Tg(TcraA18,TcrbA18)A18.2Stck
Transgene Detail
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| Symbol: |
Tg(TcraA18,TcrbA18)A18.2Stck |
| Name: |
transgene insertion A18.2, Brigitta Stockinger |
| MGI ID: |
MGI:4354506 |
| Synonyms: |
A18 |
| Transgene: |
Tg(TcraA18,TcrbA18)A18.2Stck Location: unknown
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| Alliance: |
Tg(TcraA18,TcrbA18)A18.2Stck page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(TcraA18,TcrbA18)A18.2Stck expresses
2 genes
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Mutation details: Constructs containing cDNAs for the alpha and beta chains encoding the A18 T cell receptor were cloned and placed under the control of the human CD2 promoter and LCR region. The A18 T cell clone that donated the receptor used to generate transgenic mice is a high affinity clone that recognizes very small amounts of C5 protein presented in the context of I-Ek MHC. Line A18.2 contains about 40 copies of the alpha transgene and 30 copies of the beta transgene. In addition to line 18.2, four additional transgenic lines were made.
(J:111649)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:111649 Zal T, et al., Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen. J Exp Med. 1994 Dec 1;180(6):2089-99 |
| All: |
10 reference(s) |
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Analysis Tools
