Tg(Slc6a5-icre)121Veul
Transgene Detail
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| Symbol: |
Tg(Slc6a5-icre)121Veul |
| Name: |
transgene insertion 121, Volker Eulenburg |
| MGI ID: |
MGI:4453975 |
| Synonyms: |
GlyT2-Cre |
| Transgene: |
Tg(Slc6a5-icre)121Veul Location: unknown
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| Alliance: |
Tg(Slc6a5-icre)121Veul page
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| Transgene Type: |
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Transgenic (Recombinase) |
| Mutation: |
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Insertion
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Tg(Slc6a5-icre)121Veul expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| Not Specified |
Slc6a5 |
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Mutation details: A BAC containing all coding exons of Slc6a5 and the 5' UTR was modified using a 2-step homologous recombination method resulting in the coding sequence for a codon-optimized cre (icre) including the nuclear localization signal being inserted in frame into exon 2. The modifed BAC was linearized and injected into B6D2F1 single cell zygotes. Seven founder which transmitted the transgene were obtained and five lines were analyzed (lines 118 (5 transgene copies), 121 (1 copy), 122.2 (1 copy), 122.4 (1 copy), and 128 (2 copies)). Line 121 was analyzed in greater detail.
(J:160216)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Slc6a5
(species not specified)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:160216 Ishihara N, et al., Generation of a mouse line expressing Cre recombinase in glycinergic interneurons. Genesis. 2010 Jul;48(7):437-45 |
| All: |
3 reference(s) |
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Analysis Tools
