Yap1<tm1a(KOMP)Mbp> Targeted Allele Detail MGI Mouse (MGI:4455424)

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Yap1^{tm1a(KOMP)Mbp}
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Summary

Symbol:	Yap1^{tm1a(KOMP)Mbp}
Name:	yes-associated protein 1; targeted mutation 1a, Mouse Biology Program, UC Davis
MGI ID:	MGI:4455424
Gene:	Yap1 Location: Chr9:7932000-8004597 bp, - strand Genetic Position: Chr9, 2.46 cM
Alliance:	Yap1^{tm1a(KOMP)Mbp} page
IMPC:	Yap1 gene page

Mutation
origin

Mutant Cell Lines:	DEPD00520_3_A06, DEPD00520_3_B05, DEPD00520_3_B06, DEPD00520_3_D06, DEPD00520_3_E06, DEPD00520_3_E08, DEPD00520_3_F05, DEPD00520_3_H05, DEPD00520_3_H06
Germline Transmission:	Earliest citation of germline transmission: J:204812
Parent Cell Line:	JM8A3.N1 (ES Cell)
Strain of Origin:	C57BL/6N-A^tm1Brd
Project Collection:	KOMP-CSD

Mutation
description

Allele Type:		Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:		Insertion Vector: L1L2_Bact_P
		Mutation details: The L1L2_Bact_P cassette was inserted at position 7973563 of Chromosome 9 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 7974368. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157064)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 1 line available
Carrying any Yap1 Mutation:	38 strains or lines available

References

Original:	J:157064 University of California, Davis, Alleles produced for the KOMP project by the University of California, Davis. MGI Direct Data Submission. 2010;
All:	11 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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