Acd<tm1.1Cek> Targeted Allele Detail MGI Mouse (MGI:4456177)

About Help FAQ

Acd^tm1.1Cek
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Acd^tm1.1Cek
Name:	adrenocortical dysplasia; targeted mutation 1.1, Catherine Keegan
MGI ID:	MGI:4456177
Synonyms:	Acd^tm1.1Tdl, TPP1^F
Gene:	Acd Location: Chr8:106424789-106427748 bp, - strand Genetic Position: Chr8, 53.04 cM
Alliance:	Acd^tm1.1Cek page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:160503
Parent Cell Line:	G4 (ES Cell)
Strain of Origin:	(129S6/SvEvTac x C57BL/6NCrl)F1

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: A loxP site was inserted upstream of exon 3 and an frt flanked neo cassette with a 5' loxP site was inserted downstream of exon 8. Flp mediated recombination removed the neo cassette leaving exons 3 through 8 floxed. (J:160503)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Acd Mutation:	22 strains or lines available

References

Original:	J:160503 Kibe T, et al., Telomere protection by TPP1 is mediated by POT1a and POT1b. Mol Cell Biol. 2010 Feb;30(4):1059-66
All:	3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24