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Aviltm2(cre)Fawa
Targeted Allele Detail
Summary
Symbol: Aviltm2(cre)Fawa
Name: advillin; targeted mutation 2, Fan Wang
MGI ID: MGI:4459942
Synonyms: AdvillinCre
Gene: Avil  Location: Chr10:126836578-126856863 bp, + strand  Genetic Position: Chr10, 74.48 cM, cytoband D3
Alliance: Aviltm2(cre)Fawa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:160568
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Aviltm2(cre)Fawa expression driven by 1 gene
 
Mutation details: A cre-IRES-EGFP was knocked into exon 2 of the Avil locus to achieve cre expression specifically within sensory neurons. Authors state that only male, not female, knockin animals are useful for sensory neuron-specific cre expression. The EGFP is nonfunctional. (J:160568, J:169302)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Avil (mouse)
Summary of all recombinase alleles driven by Avil.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Avil Mutation:  47 strains or lines available
References
Original:  J:160568 Zhou X, et al., Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9424-9
All:  112 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory