Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol:	Ap5z1tm1(KOMP)Wtsi
Name:	adaptor-related protein complex 5, zeta 1 subunit; targeted mutation 1, Wellcome Trust Sanger Institute
MGI ID:	MGI:4460281
Synonyms:	AP5 zeta KO
Gene:	Ap5z1  Location: Chr5:142449699-142464465 bp, + strand  Genetic Position: Chr5, 81.53 cM
Alliance:	Ap5z1tm1(KOMP)Wtsi page
IMPC:	Ap5z1 gene page

Mutant Cell Lines:	EPD0587_5_A05, EPD0587_5_A06, EPD0587_5_A08, EPD0587_5_B06, EPD0587_5_B07, EPD0587_5_B08, EPD0587_5_C08, EPD0587_5_D08, EPD0587_5_E06, EPD0587_5_E07, EPD0587_5_E08, EPD0587_5_F06, EPD0587_5_G06, EPD0587_5_H05, EPD0587_5_H06, EPD0587_5_H07
Germline Transmission:	Earliest citation of germline transmission: J:283611
Parent Cell Line:	JM8A3.N1 (ES Cell)
Strain of Origin:	C57BL/6N-Atm1Brd
Project Collection:	KOMP-CSD

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P   Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 3956 starting at position 142451972 and ending at position 142455928 of Chromosome 5 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. (J:148605, J:173534)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Ap5z1 Mutation:	42 strains or lines available

Original:	J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:	6 reference(s)