Tg(Slc2a2-cre)#Thor
Transgene Detail
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| Symbol: |
Tg(Slc2a2-cre)#Thor |
| Name: |
transgene insertion, Bernard Thorens |
| MGI ID: |
MGI:4462802 |
| Synonyms: |
pGLUT2-Cre |
| Transgene: |
Tg(Slc2a2-cre)#Thor Location: unknown
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| Alliance: |
Tg(Slc2a2-cre)#Thor page
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| Transgene Type: |
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Transgenic (Recombinase) |
| Mutation: |
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Insertion
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Tg(Slc2a2-cre)#Thor expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| Not Specified |
Slc2a2 |
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Mutation details: A cre-polyA-FRT-ampicillin-FRT targeting cassette with Slc2a2 homology fragments and a nuclear localization signal (nls) was inserted by homologous recombination at the ATG site of the Slc2a2 (Glut2) gene in EL250 bacteria. The FRT-ampicillin-FRT cassette was then removed in the presence of arabinose. Six line were obtained and crossed to reporter mice to verify cre activity. Two of these lines gave appropriate expression in pancreatic beta cells, liver, and intestine. Cre activity in the brain was in agreement with reported Slc2a2 expression. No line numbers were specified.
(J:162050)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Slc2a2
(species not specified)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:162050 Mounien L, et al., Glut2-dependent glucose-sensing controls thermoregulation by enhancing the leptin sensitivity of NPY and POMC neurons. FASEB J. 2010 Jun;24(6):1747-58 |
| All: |
3 reference(s) |
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Analysis Tools
