Hoxb8<tm4.1(cre/Esr1*)Mrc> Targeted Allele Detail MGI Mouse (MGI:4818431)

Hoxb8^{tm4.1(cre/Esr1*)Mrc}
Targeted Allele Detail

Summary

Symbol:	Hoxb8^{tm4.1(cre/Esr1*)Mrc}
Name:	homeobox B8; targeted mutation 4.1, Mario R Capecchi
MGI ID:	MGI:4818431
Synonyms:	Hoxb8-CreER^TM
Gene:	Hoxb8 Location: Chr11:96172731-96176141 bp, + strand Genetic Position: Chr11, 59.82 cM
Alliance:	Hoxb8^{tm4.1(cre/Esr1*)Mrc} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:162102
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:

Targeted (Recombinase)

Mutations:

Insertion, Intragenic deletion

Hoxb8^{tm4.1(cre/Esr1*)Mrc} expression driven by 1 gene

Mutation details: Exon 1 of Hoxb8 was replaced with cre fused to a mutated estrogen receptor followed by an FRT-flanked neo selection cassette. The neo was subsequently removed by breeding to FLPe deleter animals. In homozygous mice, the allele acts as a null allele for Hoxb8. (J:162102)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hoxb8 (mouse) Summary of all recombinase alleles driven by Hoxb8. Alliance mouse Hoxb8 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Hoxb8 Mutation:	8 strains or lines available

References

Original:	J:162102 Chen SK, et al., Hematopoietic origin of pathological grooming in Hoxb8 mutant mice. Cell. 2010 May 28;141(5):775-85
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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