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Tg(NPHS2-icre/ERT2)1Dnsh
Transgene Detail
Summary
Symbol: Tg(NPHS2-icre/ERT2)1Dnsh
Name: transgene insertion 1, Farhad R Danesh
MGI ID: MGI:4819592
Synonyms: podocin-iCreERT2
Transgene: Tg(NPHS2-icre/ERT2)1Dnsh  Location: unknown  
Alliance: Tg(NPHS2-icre/ERT2)1Dnsh page
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tg(NPHS2-icre/ERT2)1Dnsh expression driven by 1 gene
 
Mutation details: The coding sequences of (improved) icre and a tamoxifen-inducible estrogen receptor, ERT2, were fused in-frame and put under the control of 2.5 kb NPHS2 (human podocin) promoter region. The icre/ERT2 fragment was followed by the bovine growth hormone polyA (bGHpA) sequence. The linearized construct was microinjected into the pronuclei of fertilized C57BL/6 eggs. Three of four founders successfully transmitted the transgene to their offspring. (J:162633)
Inheritance:    Not Specified
Generation of Tg(NPHS2-icre/ERT2)1Dnsh.
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: NPHS2 (human)
Summary of all recombinase alleles driven by NPHS2.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:162633 Wang J, et al., Tamoxifen-inducible podocyte-specific iCre recombinase transgenic mouse provides a simple approach for modulation of podocytes in vivo. Genesis. 2010 Jul;48(7):446-51
All:  12 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory