Trp53tm1.1Dgj
Targeted Allele Detail
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| Symbol: |
Trp53tm1.1Dgj |
| Name: |
transformation related protein 53; targeted mutation 1.1, David G Johnson |
| MGI ID: |
MGI:4819616 |
| Synonyms: |
p53P, Trp53R72P |
| Gene: |
Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
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| Alliance: |
Trp53tm1.1Dgj page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:162466
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Humanized sequence) |
| Mutations: |
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Insertion, Single point mutation
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Mutation details: Exon 4 was replaced with a modified human exon 4 in which nucleotide substitution created the proline variant of the p.R72P polymorphism (SNP rs1042522). A loxP site flanked neomycin resistance gene cassette inserted upstream of exon 2 was removed by Cre-mediated recombination.
(J:162466)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Trp53 Mutation: |
240 strains or lines available
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| Original: |
J:162466 Zhu F, et al., Mouse models for the p53 R72P polymorphism mimic human phenotypes. Cancer Res. 2010 Jul 15;70(14):5851-9 |
| All: |
2 reference(s) |
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Analysis Tools
