Sox10<tm7.1(Sox10)Weg> Targeted Allele Detail MGI Mouse (MGI:4820417)

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Sox10^{tm7.1(Sox10)Weg}
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Sox10^{tm7.1(Sox10)Weg}
Name:	SRY (sex determining region Y)-box 10; targeted mutation 7.1, Michael Wegner
MGI ID:	MGI:4820417
Synonyms:	Sox10^fl
Gene:	Sox10 Location: Chr15:79039113-79048690 bp, - strand Genetic Position: Chr15, 37.7 cM
Alliance:	Sox10^{tm7.1(Sox10)Weg} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:162692
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A loxP site was inserted upstream of exon 3. The coding region was replaced with a cDNA of the rat homolog, a floxed and FRT flanked neo cassette, and an IRES-EGFP-pA cassette. Flp mediated recombination removed the neo cassette leaving the the rat cDNA floxed and the reporter cassette intact. (J:162692)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Sox10 Mutation:	33 strains or lines available

References

Original:	J:162692 Finzsch M, et al., Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage. J Cell Biol. 2010 May 17;189(4):701-12
All:	21 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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