Traf3ip2<adjm> Spontaneous Allele Detail MGI Mouse (MGI:4820827)

Traf3ip2^adjm
Spontaneous Allele Detail

Summary

Symbol:	Traf3ip2^adjm
Name:	TRAF3 interacting protein 2; atopic dermatitis from Japanese mice
MGI ID:	MGI:4820827
Gene:	Traf3ip2 Location: Chr10:39488930-39531303 bp, + strand Genetic Position: Chr10, 20.86 cM
Alliance:	Traf3ip2^adjm page

Mutation
origin

Strain of Origin:

KOR

Mutation
description

Allele Type:		Spontaneous
Mutation:		Nucleotide substitutions
		Mutation details: A spontaneous mutation resulted in a C to T transition in the second exon. The transition results in a C- terminal truncation by changing amino acid 214 from glutamine (CAG) to a stop codon (TAG). RT-PCR showed reduced transcript level and western blots of protein extracts from spleens showed no specific Ab labeling in the positions expected for TRAF3IP2.
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available Cell Lines: 0 lines available
Carrying any Traf3ip2 Mutation:	41 strains or lines available

References

Original:	J:162859 Matsushima Y, et al., An atopic dermatitis-like skin disease with hyper-IgE-emia develops in mice carrying a spontaneous recessive point mutation in the Traf3ip2 (Act1/CIKS) gene. J Immunol. 2010 Aug 15;185(4):2340-9
All:	1 reference(s)

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