About   Help   FAQ
Pdpntm1(cre)Mlkn
Targeted Allele Detail
Summary
Symbol: Pdpntm1(cre)Mlkn
Name: podoplanin; targeted mutation 1, Mark L Kahn
MGI ID: MGI:4820841
Synonyms: PdpnCre
Gene: Pdpn  Location: Chr4:142994001-143026134 bp, - strand  Genetic Position: Chr4, 77.29 cM
Alliance: Pdpntm1(cre)Mlkn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:162815
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutation:    Insertion
 
Pdpntm1(cre)Mlkn expression driven by 1 gene
 
Mutation details: Exon 1 of Pdpn was replaced with the cre cDNA and an FRT-flanked neo cassette, generating a null allele. RT-PCR performed on E14 embryos demonstrated complete loss of Pdpn mRNA. (J:162815)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pdpn (mouse)
Summary of all recombinase alleles driven by Pdpn.
 

Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdpn Mutation:  29 strains or lines available
References
Original:  J:162815 Bertozzi CC, et al., Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood. 2010 Jul 29;116(4):661-70
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory